Description
CCL4, also know as MIP-1-beta, is monokine with inflammatory and chemokinetic properties.
Binds to CCR5.
One of the major HIV-suppressive factors produced by CD8+ T-cells.
Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells.
MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B